influence of nerve tissue-derived neurotransmitters on mast cell migration

نویسندگان

p kermanizadeh from the division of immunology. faculty of medicine. tabriz university of medical sciences. tabriz. i. r. iran

p hagan . the division of infection & immunity. joseph black building. ibls. university of glasgow. glasgow gi2 bqq

dwt crompton the division of environmental & evolutionary biology. t he graham kerr building.ibls. university of glasgow. glasgow gi2 bqq. uk.

چکیده

in vitro culture systems using bone marrow cells from balb/c mice were set up in medium supplemented with spleen-derived medium. bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. the cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. some available neurotransmitters including (substance-p, histamine, serotonin, dopa, noradrenaline, acetylcholine, aspartic acid, epinephrine and nerve extracts) were tested. mast cells showed a significant morphological response to 10-3 and 10-4 m histamine, 10-9 m serotonin, and 10'2 m dopa nerve extracts induced some shape changes in mast cells.

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عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۱۴، شماره ۴، صفحات ۳۷۹-۳۸۳

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